Frankly I'd check the ignition coil/wire/boot first..
those can overheat and crack.. and the bad thing is..
they could spark when cold or the wire is bent to make proper contact, but still fail when installed.
If you got a timing light, check for sparks with that,
if you got a spark indicator plug boot, try that..
best: if you got a spare running engine, swap the coil and test with the 'new' one
I assume you checked your flywheel magnet and realigned the coil when taking a look at the flywheel key, right?
with a bit of luck the coil just moved out of alignment (bump in the road or such)
And if that's checked and known to be working
my next guess would be carb manifold gasket (sideair causing ill air/fuel ratios)
or worse valves (which show as compression issues)
Anything really (valve seat, bent pushrod, misaligned rocker... sheared tooth off the cam...)
So yeah, as suggested by hellion and bob, test as much and thoroughly as you can
for spark fuel and compression, and if everything is looking good,
you will need to take a more thorough look inside
starting with the valve cover turning the engine over slowly w/o a plug to see if there's something fishy going on with the valves or rockers..
and if that also looks okay we will all have to cross our fingers for your engine internals.
I have not seen a rod failing on just 5k, but since you ported the head and likely increased compression while being at it....
maybe you should've indeed gone for a billet rod already..
maybe yours' now slightly bent or you busted a bearing or something.
*shrugs*
I hope it's something as simple as a cracked spark plug wire.
'sid