Nope, it's fake.
1) There's only two ways that vehicle could maintain forward momentum for that long with two wheels in the air . One would be if it had locked differentials- at least one, anyway. Anyone with any kind of automotive knowledge knows dam well that running an open differential with one tire having no traction will spin the heck out of that one tire, and will apply no power to the tire with the traction- so, it would just lose speed until it dropped.
Therefore- IF that vehicle had at least one axle locked up, it would be completely impossible to loosen and remove the lug nuts, grasp and remove the wheel, and then reverse the process with that very tire whipping along at road speed. Do the math on the WRPM. The only other way to make that possible would be to modify the vehicle's brake system in order to lock, and hold locked, the brakes on the "up" side of the truck long enough to do the task. While that MIGHT be slightly possible, read my next paragraph.
2) Have you ever watched real stunt driving? The driver must constantly make mild steering corrections in order to keep the vehicle balanced even for a few seconds. The vid does not show any corrections, however minor- EVEN WHEN the guys are moving themselves and the tires around, which would largely alter the balancing, and require larger corrections.
Cute, but crap.