whether chain, belt, or friction, (assuming the same tire in all cases) the overal reduction-ratio from engine-crank to rear-hub is all that matters...
the thing that can confuse, until you look more closely, is that with friction drive the power is transferred along the tire's circumference, so the equation appears different in our mind.
but simply put, the math's exactly the same...with friction-drive, tire-diameter factors in twice...once as the "rear sprocket" and once as "tire diameter."
and while the roller's surface-speed IS the same as the vehicle's surface-speed, that fact's irrelevant to the math that's used to calculate ratio and speed.
with a small 2-stroke and a single-speed, the best bet is to pursue it's potential for high-rpm's...to a certain point, a lower gear will result in a faster vehicle than if you ask the engine to power it's way through a higher gear. it's my experience that a 32cc 2-stroke can pull a 26" bicycle best at about 20-22:1 overall-reduction. with a friction-drive, that very-roughly translates to a 1 1/8" to 1 1/4" roller.
i'll say it again, florida's getting tough on (on-road) gas-bicycles, so research is a good idea:
Gas Motorized Bicycles Illegal in Florida?