Due to the limited sizes of available clutches, it's more common to change the size of the axle sprocket rather than the engine sprocket.
For arguments sake, let's say you have a 12tooth clutch; if you mate it with a 48 tooth axle sprocket, you'll have a 4:1 gear ratio; great top speed but, it'll never get there because the clutch will burn out trying to move.
On the other hand, if you mate the 12t clutch to a 96t axle sprocket, the ratio will be 8:1, it'll take off like a bullet but won't achieve a very high top speed.
Achieving the correct gearing involves a combination of things, engine size/type, transmission type, vehicle weight, driver weight, tyre size...