There is a lot to it on racing chassis, I use to run a offset chassis on dirt oval tracks, adjustable hubs on rear axle,Left side in and right side out , right front spaced out with wider tire, left front spindle spaced downward a little to transfer a little more weight to the right rear, 6 lbs left 8 right. All settings varied to the track you run on that day.
For a play kart I don't think there is a golden rule, tires and weight make a huge difference . My play kart that I just finished was setup for a 6 to 8 hp I moved the axle back 5" from what was in the plans and ran 18" superturf tires, front end setup with a good caster camber angle and it handled and turned quick. Now that I upgraded to the 13 hp and put on 20" knobby's it don't turn , to much traction but it sure rides smooth.
Axle should be a couple more inches back and engine couple inches forward witch would put the seat a couple inches forward