Yes, they react very well. The kart I'm using right now I did not build, I bought it as an instant gratification thing until I build my own. I didn't know a blessed thing about CVT's 'till I got it, and I consider my Comet 40 to be the next best thing to a gearbox. My kart (see avatar) has a GX340 and some decent sized rear turf tires. My final ratio is aournd 5:1. I may lower that slightly, but nevertheless I am quite pleased with the CVT. Takeoffs are smooth with a light foot, and if I punch it, the debris flies. Donuts, drifting, and powerslides are impressive, as are transitions between high and low roadspeeds.
And yes, the next step for this thang is some suspension. I was getting jostled right out of my seat offroad, so one of my mods was a seatbelt. So far I haven't done much else- kill switch on steering colums, halogen headlight on rollbar, padded boat set (was just plywood before <OUCH!> and I changed the brake pedal to immediately left of the throttle for right-foot-only operation.