What's better? Blue or red?
Yes- a "dead axle" (single wheel drive) typically exhibits better road manners. On the other hand, traction in less-than-perfect-conditions can be pretty dismal. There is no drifting either. By the same token, a live-axle equipped kart can perform quite admirably on pavement if it's set up correctly.
So basically, it boils down to your needs, your preference, and the kart itself.