General rule of thumb..... The bigger the number before :1 means the more torque / power it will have. The smaller the number,the more speed it will have. The average baseline gear ratio for a kart is 6:1,being on a simple yard kart with 11" tires. It's when you change the kart, ie for off road, more weight, or bigger tires..... That's when the need for a different ratio comes in. The more resistance you have (all of the above ) ,the more ooomph you need to get going and stay going. If you are using 15" tires with a CC, then you have to gear down to around 8:1. Depending on how and where you drive, you might get away with 7.2:1. Anything more than that, you're gonna need a torque converter and still need a lower ratio. Does that make sense?
My single seat yellow jacket has a modded gx160 and in the 9hp+ range. I run 11.5" tall tires, the kart and me weigh in around 300lbs. My current ratio is 4.8:1..... It's a yard kart turned street runner.

lolgoku

That ratio works for me and my set up. If it was a 2 seater, I'd be back at 5.8:1-6.4:1......